An Ultra-High Time Resolution Cosmic-Ray Detection Mode for the Murchison Widefield Array

The radio-wavelength detection of extensive air showers (EASs) initiated by cosmic-ray interactions in the Earth's atmosphere is a promising technique for investigating the origin of these particles and the physics of their interactions. The Low-frequency Array (LOFAR) and the Owens Valley Long Wavelength Array (OVRO-LWA) have both demonstrated that the dense cores of low-frequency radio telescope arrays yield detailed information on the radiation ground pattern, which can be used to reconstruct key EAS properties and infer the primary cosmic-ray composition. Here, we demonstrate a new observation mode of the Murchison Widefield Array (MWA), tailored to the observation of the sub-microsecond coherent bursts of radiation produced by EAS. We first show how an aggregate 30.72MHz bandwidth (3072×10kHz frequency channels) recorded at 0.1ms resolution with the MWA's voltage capture system (VCS) can be synthesized back to the full bandwidth Nyquist resolution of 16.3ns. This process, which involves "inverting"two sets of polyphase filterbanks, retains 90.5% of the signal-to-noise of a cosmic-ray signal. We then demonstrate the timing and positional accuracy of this mode by resolving the location of a calibrator pulse to within 5m. Finally, preliminary observations show that the rate of nanosecond radio-frequency interference (RFI) events is 0.1Hz, much lower than that found at the sites of other radio telescopes that study cosmic rays. We conclude that the identification of cosmic rays at the MWA, and hence with the low-frequency component of the Square Kilometre Array, is feasible with minimal loss of efficiency due to RFI

Drifting sub-pulses in two newly discovered pulsars

We have detected the rare phenomenon of stable, drifting sub-pulse behaviour in two pulsars discovered in the recent Swinburne intermediate latitude pulsar survey. The pulsars; PSR J1231-47 and PSR J1919+0134, have approximate periods (P) of 1.873 and 1.6039 seconds respectively. Both pulsars have multi-component profiles, and distinct drifting is observed across them. We have identified a single drift mode in both pulsars: the drift rate for PSR J1231-47 being 5.4(1) ms P^{-1} and 5.8(2) ms P^{-1} for PSR 1919+0134. The drifting is linear across the profile with no departure from linearity at the edges within the sensitivity of our observations.Comment: 4 pages, 2 figures. Accepted by Monthly Notices of the Royal Astronomical Societ

Enabling a High Throughput Real Time Data Pipeline for a Large Radio Telescope Array with GPUs

The Murchison Widefield Array (MWA) is a next-generation radio telescope currently under construction in the remote Western Australia Outback. Raw data will be generated continuously at 5GiB/s, grouped into 8s cadences. This high throughput motivates the development of on-site, real time processing and reduction in preference to archiving, transport and off-line processing. Each batch of 8s data must be completely reduced before the next batch arrives. Maintaining real time operation will require a sustained performance of around 2.5TFLOP/s (including convolutions, FFTs, interpolations and matrix multiplications). We describe a scalable heterogeneous computing pipeline implementation, exploiting both the high computing density and FLOP-per-Watt ratio of modern GPUs. The architecture is highly parallel within and across nodes, with all major processing elements performed by GPUs. Necessary scatter-gather operations along the pipeline are loosely synchronized between the nodes hosting the GPUs. The MWA will be a frontier scientific instrument and a pathfinder for planned peta- and exascale facilities.Comment: Version accepted by Comp. Phys. Com

Rotation measure variations for 20 millisecond pulsars

We report on variations in the mean position angle of the 20 millisecond pulsars being observed as part of the Parkes Pulsar Timing Array (PPTA) project. It is found that the observed variations are dominated by changes in the Faraday rotation occurring in the Earth's ionosphere. Two ionospheric models are used to correct for the ionospheric contribution and it is found that one based on the International Reference Ionosphere gave the best results. Little or no significant long-term variation in interstellar RM was found with limits typically about 0.1 rad m$^{-2}$ yr$^{-1}$ in absolute value. In a few cases, apparently significant RM variations over timescales of a few 100 days or more were seen. These are unlikely to be due to localised magnetised regions crossing the line of sight since the implied magnetic fields are too high. Most probably they are statistical fluctuations due to random spatial and temporal variations in the interstellar electron density and magnetic field along the line of sight.Comment: Accepted for publication in Astrophysics & Space Scienc

Gravitational Radiation from Compact Binary Pulsars

An outstanding question in modern Physics is whether general relativity (GR) is a complete description of gravity among bodies at macroscopic scales. Currently, the best experiments supporting this hypothesis are based on high-precision timing of radio pulsars. This chapter reviews recent advances in the field with a focus on compact binary millisecond pulsars with white-dwarf (WD) companions. These systems - if modeled properly - provide an unparalleled test ground for physically motivated alternatives to GR that deviate significantly in the strong-field regime. Recent improvements in observational techniques and advances in our understanding of WD interiors have enabled a series of precise mass measurements in such systems. These masses, combined with high-precision radio timing of the pulsars, result to stringent constraints on the radiative properties of gravity, qualitatively very different from what was available in the past.Comment: Short review chapter to appear in "Gravitational Wave Astrophysics" by Springer-Verlag, edited by Carlos F. Sopuerta; v3: a few major corrections and updated references. Comments are welcome

Soluble Sema4D in Plasma of Head and Neck Squamous Cell Carcinoma Patients Is Associated With Underlying Non-Inflamed Tumor Profile

Semaphorin 4D (Sema4D) is a glycoprotein that is expressed by several tumors and immune cells. It can function as a membrane bound protein or as a cleaved soluble protein (sSema4D). We sought to investigate the translational potential of plasma sSema4D as an immune marker in plasma of patients with head and neck squamous cell carcinoma (HNSCC). Paired peripheral blood and tumor tissue samples of 104 patients with HNSCC were collected at the same time point to allow for real time analysis. Scoring of the histological inflammatory subtype (HIS) was carried out using Sema4D immunohistochemistry on the tumor tissue. sSema4D was detected in plasma using direct ELISA assay. Defining elevated sSema4D as values above the 95th percentile in healthy controls, our data showed that sSema4D levels in plasma were elevated in 25.0% (95% CI, 16.7–34.9%) of the patients with HNSCC and showed significant association with HIS immune excluded (HIS-IE) (p = 0.007), Sema4D+ve tumor cells (TCs) (p = 0.018) and PD-L1+ve immune cells (ICs) (p = 0.038). A multi-variable logistic regression analysis showed that HIS was significantly (P = 0.004) associated with elevated sSema4D, an association not explained by available patient-level factors. Using the IO-360 nanoString platform, differential gene expression (DGE) analysis of 10 HNSCC tumor tissues showed that patients with high sSema4D in plasma (HsS4D) clustered as IFN-γ negative tumor immune signature and were mostly HIS-IE. The IC type in the HsS4D paired tumor tissue was predominantly myeloid, while the lymphoid compartment was higher in the low sSema4D (LsS4D). The Wnt signaling pathway was upregulated in the HsS4D group. Further analysis using the IO-360, 770 gene set, showed significant non-inflamed profile of the HsS4D tumors compared to the LsS4D. In conclusion, our data reveals an association between sSema4D and the histological inflammatory subtype. © Copyright © 2021 Younis, Ghita, Elnaggar, Chaisuparat, Theofilou, Dyalram, Ord, Davila, Tallon, Papadimitriou, Webb, Bentzen and Lubek